JAK1/3 signaling pathways are key initiators of T(H)2 differentiation and lung allergic responses

BACKGROUND: Janus kinases (JAK) are regulators of signaling through cytokine receptors. The importance of JAK1/3 signaling on Th2 differentiation and development of lung allergic responses has not been investigated. OBJECTIVE: To examine a selective JAK1/3 inhibitor (R256) on differentiation of Th s...

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Bibliographic Details
Main Authors: Ashino, Shigeru, Takeda, Katsuyuki, Li, Hui, Taylor, Vanessa, Joetham, Anthony, Pine, Polly R., Gelfand, Erwin W.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972277/
https://ncbi.nlm.nih.gov/pubmed/24365136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2013.10.036
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