Estrogen controls the survival of BRCA1-deficient cells via a PI3K–NRF2-regulated pathway

Mutations in the tumor suppressor BRCA1 predispose women to breast and ovarian cancers. The mechanism underlying the tissue-specific nature of BRCA1’s tumor suppression is obscure. We previously showed that the antioxidant pathway regulated by the transcription factor NRF2 is defective in BRCA1-defi...

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Hlavní autoři: Gorrini, Chiara, Gang, Bevan P., Bassi, Christian, Wakeham, Andrew, Baniasadi, Shakiba Pegah, Hao, Zhenyue, Li, Wanda Y., Cescon, David W., Li, Yen-Ting, Molyneux, Sam, Penrod, Nadia, Lupien, Mathieu, Schmidt, Edward E., Stambolic, Vuk, Gauthier, Mona L., Mak, Tak W.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970526/
https://ncbi.nlm.nih.gov/pubmed/24567396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1324136111
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