Reduced bioenergetics and toll-like receptor 1 function in human polymorphonuclear leukocytes in aging

Aging is associated with a progressive decline in immune function (immunosenescence) resulting in an increased susceptibility to viral and bacterial infections. Here we show reduced expression of Toll-like receptor 1 (TLR1) in polymorphonuclear leukocytes (PMN) and an underlying age-dependent defici...

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Bibliografiske detaljer
Main Authors: Qian, Feng, Guo, Xiuyang, Wang, Xiaomei, Yuan, Xiaoling, Chen, Shu, Malawista, Stephen E., Bockenstedt, Linda K., Allore, Heather G., Montgomery, Ruth R.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2014
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969281/
https://ncbi.nlm.nih.gov/pubmed/24595889
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