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A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide
A small molecule, protein mimetic based approach is shown to specifically inhibit lipid catalysed self-assembly of islet amyloid polypeptide (IAPP). The lipid-bound oligomerization of this peptide is implicated in cellular dysfunction of insulin secreting β-cells in type II diabetes.
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3968531/ https://ncbi.nlm.nih.gov/pubmed/23579860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cc41452c |
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