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Combinatorial H3K9acS10ph Histone Modifications in IgH Locus S Regions Target 14-3-3 Adaptors and AID to Specify Antibody Class Switch DNA Recombination
Class switch DNA recombination (CSR) is central to the antibody response, as it changes the immunoglobulin heavy chain (IgH) constant region, thereby diversifying biological effector functions of antibodies. The AID-centered CSR machinery excises and rejoins DNA between an upstream (donor) and a dow...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3951903/ https://ncbi.nlm.nih.gov/pubmed/24209747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.09.031 |
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