Combinatorial H3K9acS10ph Histone Modifications in IgH Locus S Regions Target 14-3-3 Adaptors and AID to Specify Antibody Class Switch DNA Recombination

Class switch DNA recombination (CSR) is central to the antibody response, as it changes the immunoglobulin heavy chain (IgH) constant region, thereby diversifying biological effector functions of antibodies. The AID-centered CSR machinery excises and rejoins DNA between an upstream (donor) and a dow...

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Bibliographic Details
Main Authors: Li, Guideng, White, Clayton A., Lam, Tonika, Pone, Egest J., Tran, Daniel C., Hayama, Ken L., Zan, Hong, Xu, Zhenming, Casali, Paolo
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951903/
https://ncbi.nlm.nih.gov/pubmed/24209747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.09.031
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