Crosstalk between cGAS DNA sensor and Beclin-1 autophagy protein shapes innate anti-microbial immune responses

Robust immune responses are essential for eliminating pathogens, but must be metered to avoid prolonged immune activation and potential host damage. Upon recognition of microbial DNA, the cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthetase, or cGAS, produces the second messenger cGAMP to initiate...

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Sonraí Bibleagrafaíochta
Main Authors: Liang, Qiming, Seo, Gil Ju, Choi, Youn Jung, Kwak, Mi-Jeong, Ge, Jianning, Rodgers, Mary A, Shi, Mude, Leslie, Benjamin J., Hopfner, Karl-Peter, Ha, Taekjip, Oh, Byung-Ha, Jung, Jae U.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950946/
https://ncbi.nlm.nih.gov/pubmed/24528868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.01.009
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