Crosstalk between cGAS DNA sensor and Beclin-1 autophagy protein shapes innate anti-microbial immune responses

Robust immune responses are essential for eliminating pathogens, but must be metered to avoid prolonged immune activation and potential host damage. Upon recognition of microbial DNA, the cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthetase, or cGAS, produces the second messenger cGAMP to initiate...

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Hauptverfasser: Liang, Qiming, Seo, Gil Ju, Choi, Youn Jung, Kwak, Mi-Jeong, Ge, Jianning, Rodgers, Mary A, Shi, Mude, Leslie, Benjamin J., Hopfner, Karl-Peter, Ha, Taekjip, Oh, Byung-Ha, Jung, Jae U.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950946/
https://ncbi.nlm.nih.gov/pubmed/24528868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.01.009
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