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The Dynamics of Compound, Transcript, and Protein Effects After Treatment With 2OMePS Antisense Oligonucleotides in mdx Mice
Antisense-mediated exon skipping is currently in clinical development for Duchenne muscular dystrophy (DMD) to amend the consequences of the underlying genetic defect and restore dystrophin expression. Due to turnover of compound, transcript, and protein, chronic treatment with effector molecules (a...
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主要な著者: | , , , , , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
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Nature Publishing Group
2014
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オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3950770/ https://ncbi.nlm.nih.gov/pubmed/24549299 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2014.1 |
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