Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies

Irisin was identified as a myokine secreted by contracting skeletal muscle, possibly mediating some exercise health benefits via ‘browning’ of white adipose tissue. However, a controversy exists concerning irisin origin, regulation and function in humans. Thus, we have explored Fndc5 gene and irisin...

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Hauptverfasser: Kurdiova, Timea, Balaz, Miroslav, Vician, Marek, Maderova, Denisa, Vlcek, Miroslav, Valkovic, Ladislav, Srbecky, Miroslav, Imrich, Richard, Kyselovicova, Olga, Belan, Vitazoslav, Jelok, Ivan, Wolfrum, Christian, Klimes, Iwar, Krssak, Martin, Zemkova, Erika, Gasperikova, Daniela, Ukropec, Jozef, Ukropcova, Barbara
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons Ltd 2014
Schlagworte:
Skeletal Muscle and Exercise
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948565/
https://ncbi.nlm.nih.gov/pubmed/24297848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.264655
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