Combining Human and Rat Sequences in Her-2 DNA Vaccines Blunts Immune Tolerance and Drives Antitumor Immunity

Immune tolerance to tumor-associated self-antigens poses a major challenge in the ability to mount an effective cancer vaccine response. To overcome immune tolerance to HER-2, we formulated DNA vaccines that express both human HER-2 and heterologous rat Neu sequences in separate plasmids or as singl...

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Detaylı Bibliyografya
Asıl Yazarlar: Jacob, Jennifer B., Quaglino, Elena, Radkevich-Brown, Olga, Jones, Richard F., Piechocki, Marie P., Reyes, Joyce D., Weise, Amy, Amici, Augusto, Wei, Wei-Zen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947604/
https://ncbi.nlm.nih.gov/pubmed/20048073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2554
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