The dual role of HOP2 in mammalian meiotic homologous recombination

Deletion of Hop2 in mice eliminates homologous chromosome synapsis and disrupts double-strand break (DSB) repair through homologous recombination. HOP2 in vitro shows two distinctive activities: when it is incorporated into a HOP2–MND1 complex it stimulates DMC1 and RAD51 recombination activities an...

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Bibliographic Details
Main Authors: Pezza, Roberto J., Voloshin, Oleg N., Volodin, Alexander A., Boateng, Kingsley A., Bellani, Marina A., Mazin, Alexander V., Camerini-Otero, R. Daniel
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936763/
https://ncbi.nlm.nih.gov/pubmed/24304900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1234
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