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Expeditious Synthesis, Enantiomeric Resolution and Enantiomer Functional Characterization of (4-(4-bromophenyl)-3a, 4, 5, 9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4BP-TQS): an Allosteric agonist-Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptors
An expeditious microwave-assisted synthesis of 4BP-TQS, its enantiomeric separation and their functional evaluations is reported. Electrophysiological characterization in Xenopus oocytes revealed that activity exclusively resided in the (+)-enantiomer 1b (GAT107) and (−)-enantiomer 1a did not affect...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3933094/ https://ncbi.nlm.nih.gov/pubmed/24090443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401267t |
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