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Benzimidazoisoquinolines: A New Class of Rapidly Metabolized Aryl Hydrocarbon Receptor (AhR) Ligands that Induce AhR-Dependent Tregs and Prevent Murine Graft-Versus-Host Disease
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that plays multiple roles in regulation of immune and inflammatory responses. The ability of certain AhR ligands to induce regulatory T cells (Tregs) has generated interest in developing AhR ligands for therapeutic treatm...
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Main Authors: | , , , , , , , , , |
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Format: | Artigo |
Language: | Inglês |
Published: |
Public Library of Science
2014
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Subjects: | |
Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3929365/ https://ncbi.nlm.nih.gov/pubmed/24586378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088726 |
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