Fabrication of nanoadjuvant with poly-ε-caprolactone (PCL) for developing a single-shot vaccine providing prolonged immunity

PURPOSE: The aim of the study was to load a model antigen, tetanus toxoid (TT), in poly-ε-caprolactone nanoparticles (PCL NPs) of two size ranges, ie, mean 61.2 nm (small) and 467.6 nm (large), and study its effect on macrophage polarization as well as antigen presentation in human monocyte-derived...

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Autores principales: Prashant, Chandravilas Keshvan, Bhat, Madhusudan, Srivastava, Sandeep Kumar, Saxena, Ankit, Kumar, Manoj, Singh, Amar, Samim, Mohammed, Ahmad, Farhan Jalees, Dinda, Amit Kumar
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3928464/
https://ncbi.nlm.nih.gov/pubmed/24611010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S55892
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