Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia

BACKGROUND: In mammalians, HIF is a master regulator of hypoxia gene expression through direct binding to DNA, while its role in microRNA expression regulation, critical in the hypoxia response, is not elucidated genome wide. Our aim is to investigate in depth the regulation of microRNA expression b...

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Hlavní autoři: Camps, Carme, Saini, Harpreet K, Mole, David R, Choudhry, Hani, Reczko, Martin, Guerra-Assunção, José Afonso, Tian, Ya-Min, Buffa, Francesca M, Harris, Adrian L, Hatzigeorgiou, Artemis G, Enright, Anton J, Ragoussis, Jiannis
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3928101/
https://ncbi.nlm.nih.gov/pubmed/24517586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-28
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