A scoring strategy combining statistics and functional genomics supports a possible role for common polygenic variation in autism

Autism spectrum disorders (ASD) are highly heritable complex neurodevelopmental disorders with a 4:1 male: female ratio. Common genetic variation could explain 40–60% of the variance in liability to autism. Because of their small effect, genome-wide association studies (GWASs) have only identified a...

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Dades bibliogràfiques
Autors principals: Carayol, Jérôme, Schellenberg, Gerard D., Dombroski, Beth, Amiet, Claire, Génin, Bérengère, Fontaine, Karine, Rousseau, Francis, Vazart, Céline, Cohen, David, Frazier, Thomas W., Hardan, Antonio Y., Dawson, Geraldine, Rio Frio, Thomas
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2014
Matèries:
Genetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3927086/
https://ncbi.nlm.nih.gov/pubmed/24600472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2014.00033
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