GTP Dysregulation in Bacillus subtilis Cells Lacking (p)ppGpp Results in Phenotypic Amino Acid Auxotrophy and Failure To Adapt to Nutrient Downshift and Regulate Biosynthesis Genes

The nucleotide (p)ppGpp inhibits GTP biosynthesis in the Gram-positive bacterium Bacillus subtilis. Here we examined how this regulation allows cells to grow in the absence of amino acids. We showed that B. subtilis cells lacking (p)ppGpp, due to either deletions or point mutations in all three (p)p...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kriel, Allison, Brinsmade, Shaun R., Tse, Jessica L., Tehranchi, Ashley K., Bittner, Alycia N., Sonenshein, Abraham L., Wang, Jue D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2014
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911124/
https://ncbi.nlm.nih.gov/pubmed/24163341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00918-13
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