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The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in rats

The hypocretin receptor (HcrtR) antagonist almorexant (ALM) has potent hypnotic actions but little is known about neurocognitive performance in the presence of ALM. HcrtR antagonists are hypothesized to induce sleep by disfacilitation of wake-promoting systems whereas GABA(A) receptor modulators suc...

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Autori principali: Morairty, Stephen R., Wilk, Alan J., Lincoln, Webster U., Neylan, Thomas C., Kilduff, Thomas S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907703/
https://ncbi.nlm.nih.gov/pubmed/24550767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2014.00003
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