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Transmembrane allosteric coupling of the gates in a potassium channel

It has been hypothesized that transmembrane allostery is the basis for inactivation of the potassium channel KcsA: opening the intracellular gate is spontaneously followed by ion expulsion at the extracellular selectivity filter. This suggests a corollary: following ion expulsion at neutral pH, a sp...

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Bibliografske podrobnosti
Main Authors: Wylie, Benjamin J., Bhate, Manasi P., McDermott, Ann E.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890889/
https://ncbi.nlm.nih.gov/pubmed/24344306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319577110
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