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Paradoxical One-ion Pore Behavior of the Long β-Helical Peptide of Marine Cytotoxic Polytheonamide B

The cytotoxic 48-mer peptide, polytheonamide B (pTB), from a marine sponge forms a β(6.3)-helix with an inner diameter of 4 Å and a length of 45 Å, features that allow the selective permeation of monovalent cations across targeted cell membranes. To characterize this long, narrow pore, electrophysio...

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Sonraí Bibleagrafaíochta
Main Authors: Iwamoto, Masayuki, Matsunaga, Shigeki, Oiki, Shigetoshi
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887386/
https://ncbi.nlm.nih.gov/pubmed/24407373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03636
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