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Paradoxical One-ion Pore Behavior of the Long β-Helical Peptide of Marine Cytotoxic Polytheonamide B
The cytotoxic 48-mer peptide, polytheonamide B (pTB), from a marine sponge forms a β(6.3)-helix with an inner diameter of 4 Å and a length of 45 Å, features that allow the selective permeation of monovalent cations across targeted cell membranes. To characterize this long, narrow pore, electrophysio...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3887386/ https://ncbi.nlm.nih.gov/pubmed/24407373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03636 |
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