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A Multi-Scale Model of Hepcidin Promoter Regulation Reveals Factors Controlling Systemic Iron Homeostasis

Systemic iron homeostasis involves a negative feedback circuit in which the expression level of the peptide hormone hepcidin depends on and controls the iron blood levels. Hepcidin expression is regulated by the BMP6/SMAD and IL6/STAT signaling cascades. Deregulation of either pathway causes iron-re...

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Detalhes bibliográficos
Main Authors: Casanovas, Guillem, Banerji, Anashua, d'Alessio, Flavia, Muckenthaler, Martina U., Legewie, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879105/
https://ncbi.nlm.nih.gov/pubmed/24391488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003421
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