TNF-α and IFN-s-Dependent Muscle Decay Is Linked to NF-κB- and STAT-1α-Stimulated Atrogin1 and MuRF1 Genes in C2C12 Myotubes

TNF-α was shown to stimulate mitogenicity in C2C12 myoblasts. Selected cytokines TNF-α, IFNα, or IFNγ reduced the expression of myosin heavy chain (MyHC IIa) when given together. Molecular mechanisms of cytokine activities were controlled by NF-κB and JAK/STAT signaling pathways, as metabolic inhibi...

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Detalhes bibliográficos
Main Authors: Pijet, Barbara, Pijet, Maja, Litwiniuk, Anna, Gajewska, Małgorzata, Pająk, Beata, Orzechowski, Arkadiusz
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3877628/
https://ncbi.nlm.nih.gov/pubmed/24453411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/171437
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