Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine

Mutation in the IDH1 or IDH2 genes occurs frequently in gliomas and other human malignancies. In intermediate grade gliomas, IDH1 mutation is found in over 70% of tumors. These mutations impart the mutant IDH enzyme with a neomorphic activity – the ability to synthesize 2-hydroxyglutarate (2-HG). Th...

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Main Authors: Turcan, Sevin, Fabius, Armida W. M., Borodovsky, Alexandra, Pedraza, Alicia, Brennan, Cameron, Huse, Jason, Viale, Agnes, Riggins, Gregory J., Chan, Timothy A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858559/
https://ncbi.nlm.nih.gov/pubmed/24077826
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