Plasma amino acids imbalance in cirrhotic patients disturbs the tricarboxylic acid cycle of dendritic cell

An imbalance of plasma amino acids (AA) is observed cirrhotic patients. Here we report that the imbalance suppresses the maturation of dendritic cells (DCs) by reducing the intracellular ATP due to interference with the mitochondrial tricarboxylic acid (TCA) cycle. We used serum-free culture medium...

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Huvudupphovsmän: Kakazu, Eiji, Kondo, Yasuteru, Kogure, Takayuki, Ninomiya, Masashi, Kimura, Osamu, Ueno, Yoshiyuki, Shimosegawa, Tooru
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857572/
https://ncbi.nlm.nih.gov/pubmed/24322372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03459
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