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Role of P-Glycoprotein Expression and Function in Cystinotic Renal Proximal Tubular Cells
P-glycoprotein (P-gp) is an ATP-dependent transporter localized at the apical membrane of the kidney proximal tubules, which plays a role in the efflux of cationic and amphipathic endogenous waste products and xenobiotics, such as drugs, into urine. Studies in mice deficient in P-gp showed generaliz...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
MDPI
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3857058/ https://ncbi.nlm.nih.gov/pubmed/24309308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics3040782 |
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