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Blinatumomab induces autologous T-cell killing of chronic lymphocytic leukemia cells

Chronic lymphocytic leukemia is an incurable B-cell malignancy that is associated with tumor cell-mediated T-cell dysfunction. It therefore represents a challenging disease for T-cell immunotherapeutics. The CD19/CD3 bi-specific antibody construct blinatumomab (AMG103 or MT103) has been tested clini...

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Bibliografski detalji
Glavni autori: Wong, Ryan, Pepper, Chris, Brennan, Paul, Nagorsen, Dirk, Man, Stephen, Fegan, Chris
Format: Artigo
Jezik:Inglês
Izdano: Ferrata Storti Foundation 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857012/
https://ncbi.nlm.nih.gov/pubmed/23812940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.082248
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