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Remarkable Stabilization of Plasminogen Activator Inhibitor 1 in a “Molecular Sandwich” Complex
Plasminogen activator inhibitor 1 (PAI-1) levels are elevated in a number of life threatening conditions and often correlate with unfavorable outcomes. Spontaneous inactivation due to active to latent transition limits PAI-1 activity in vivo. While endogenous vitronectin (Vn) stabilizes PAI-1 by 1.5...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3855604/ https://ncbi.nlm.nih.gov/pubmed/23734661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400470s |
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