Targeted Ablation of Crb1 and Crb2 in Retinal Progenitor Cells Mimics Leber Congenital Amaurosis

Development in the central nervous system is highly dependent on the regulation of the switch from progenitor cell proliferation to differentiation, but the molecular and cellular events controlling this process remain poorly understood. Here, we report that ablation of Crb1 and Crb2 genes results i...

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Main Authors: Pellissier, Lucie P., Alves, Celso Henrique, Quinn, Peter M., Vos, Rogier M., Tanimoto, Naoyuki, Lundvig, Ditte M. S., Dudok, Jacobus J., Hooibrink, Berend, Richard, Fabrice, Beck, Susanne C., Huber, Gesine, Sothilingam, Vithiyanjali, Garcia Garrido, Marina, Le Bivic, André, Seeliger, Mathias W., Wijnholds, Jan
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3854796/
https://ncbi.nlm.nih.gov/pubmed/24339791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003976
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