Acteoside Suppresses RANKL-Mediated Osteoclastogenesis by Inhibiting c-Fos Induction and NF-κB Pathway and Attenuating ROS Production

Numerous studies have reported that inflammatory cytokines are important mediators for osteoclastogenesis, thereby causing excessive bone resorption and osteoporosis. Acteoside, the main active compound of Rehmannia glutinosa, which is used widely in traditional Oriental medicine, has anti-inflammat...

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Bibliographic Details
Main Authors: Lee, Seung-Youp, Lee, Keun-Soo, Yi, Sea Hyun, Kook, Sung-Ho, Lee, Jeong-Chae
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851776/
https://ncbi.nlm.nih.gov/pubmed/24324641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080873
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