Functional examination of MLH1, MSH2, and MSH6 intronic mutations identified in Danish colorectal cancer patients

BACKGROUND: Germ-line mutations in the DNA mismatch repair genes MLH1, MSH2, and MSH6 predispose to the development of colorectal cancer (Lynch syndrome or hereditary nonpolyposis colorectal cancer). These mutations include disease-causing frame-shift, nonsense, and splicing mutations as well as lar...

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Autores principales: Petersen, Sanne M, Dandanell, Mette, Rasmussen, Lene J, Gerdes, Anne-Marie, Krogh, Lotte N, Bernstein, Inge, Okkels, Henrik, Wikman, Friedrik, Nielsen, Finn C, Hansen, Thomas v O
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3850734/
https://ncbi.nlm.nih.gov/pubmed/24090359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-14-103
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