Mammalian Target of Rapamycin Complex I (mTORC1) Activity in Ras Homologue Enriched in Brain (Rheb)-Deficient Mouse Embryonic Fibroblasts

The Ras-like GTPase Rheb has been identified as a crucial activator of mTORC1. Activation most likely requires a direct interaction between Rheb and mTOR, but the exact mechanism remains unclear. Using a panel of Rheb-deficient mouse embryonic fibroblasts (MEFs), we show that Rheb is indeed essentia...

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Main Authors: Groenewoud, Marlous J., Goorden, Susan M. I., Kassies, Jorien, Pellis-van Berkel, Wendy, Lamb, Richard F., Elgersma, Ype, Zwartkruis, Fried J. T.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841147/
https://ncbi.nlm.nih.gov/pubmed/24303063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081649
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