Intracellular ATP binding is required to activate the slowly activating K(+) channel I(Ks)

Gating of ion channels by ligands is fundamental to cellular function, and ATP serves as both an energy source and a signaling molecule that modulates ion channel and transporter functions. The slowly activating K(+) channel I(Ks) in cardiac myocytes is formed by KCNQ1 and KCNE1 subunits that conduc...

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Bibliographic Details
Main Authors: Li, Yang, Gao, Junyuan, Lu, Zhongju, McFarland, Kelli, Shi, Jingyi, Bock, Kevin, Cohen, Ira S., Cui, Jianmin
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839694/
https://ncbi.nlm.nih.gov/pubmed/24190995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1315649110
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