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Bleomycin induces endothelial mesenchymal transition through activation of mTOR pathway: a possible mechanism contributing to the sclerotherapy of venous malformations

BACKGROUND AND PURPOSE: Bleomycin (BLM), one of the most common sclerosants, is often used to treat venous malformations (VMs). The present study was designed to investigate whether endothelial mesenchymal transition (EndoMT) contributes to the therapeutic effects of BLM. EXPERIMENTAL APPROACH: Endo...

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Autori principali: Zhang, Wei, Chen, Gang, Ren, Jian-Gang, Zhao, Yi-Fang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838696/
https://ncbi.nlm.nih.gov/pubmed/23992520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12355
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