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Bleomycin induces endothelial mesenchymal transition through activation of mTOR pathway: a possible mechanism contributing to the sclerotherapy of venous malformations

BACKGROUND AND PURPOSE: Bleomycin (BLM), one of the most common sclerosants, is often used to treat venous malformations (VMs). The present study was designed to investigate whether endothelial mesenchymal transition (EndoMT) contributes to the therapeutic effects of BLM. EXPERIMENTAL APPROACH: Endo...

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Detalhes bibliográficos
Main Authors: Zhang, Wei, Chen, Gang, Ren, Jian-Gang, Zhao, Yi-Fang
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838696/
https://ncbi.nlm.nih.gov/pubmed/23992520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12355
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