Cancer Stem-like Cell Properties are Regulated by EGFR/AKT/β-catenin Signaling and Preferentially Inhibited by Gefitinib in Nasopharyngeal Carcinoma

We report that the EGFR pathway plays a critical role in regulating cancer stem-like cells (CSCs) in nasopharyngeal carcinoma (NPC), one of the most common malignant tumors in Southeast Asia. Effects of EGFR on maintaining CSCs are mainly mediated by AKT signaling, and β-catenin is responsible for g...

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Detalhes bibliográficos
Main Authors: Ma, Lei, Zhang, Gong, Miao, Xiao-Bo, Deng, Xu-Bin, Wu, Yue, Liu, Ying, Jin, Zhi-Ru, Li, Xi-Qing, Liu, Qiu-Zhen, Sun, Du-Xin, Testa, Joseph R., Yao, Kai-Tai, Xiao, Guang-Hui
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831031/
https://ncbi.nlm.nih.gov/pubmed/23461856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.12226
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