Can Non-lytic CD8+ T Cells Drive HIV-1 Escape?

The CD8+ T cell effector mechanisms that mediate control of HIV-1 and SIV infections remain poorly understood. Recent work suggests that the mechanism may be primarily non-lytic. This is in apparent conflict with the observation that SIV and HIV-1 variants that escape CD8+ T cell surveillance are fr...

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Bibliographic Details
Main Authors: Seich al Basatena, Nafisa-Katrin, Chatzimichalis, Konstantinos, Graw, Frederik, Frost, Simon D. W., Regoes, Roland R., Asquith, Becca
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828169/
https://ncbi.nlm.nih.gov/pubmed/24244151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003656
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