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Novel Insights into Eukaryotic γ-Glutamyltranspeptidase 1 from the Crystal Structure of the Glutamate-bound Human Enzyme

The enzyme γ-glutamyltranspeptidase 1 (GGT1) is a conserved member of the N-terminal nucleophile hydrolase family that cleaves the γ-glutamyl bond of glutathione and other γ-glutamyl compounds. In animals, GGT1 is expressed on the surface of the cell and has critical roles in maintaining cysteine le...

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Main Authors: West, Matthew B., Chen, Yunyu, Wickham, Stephanie, Heroux, Ann, Cahill, Kyle, Hanigan, Marie H., Mooers, Blaine H. M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814782/
https://ncbi.nlm.nih.gov/pubmed/24047895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.498139
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