Temozolomide downregulates P-glycoprotein expression in glioblastoma stem cells by interfering with the Wnt3a/glycogen synthase-3 kinase/β-catenin pathway

BACKGROUND: Glioblastoma multiforme stem cells display a highly chemoresistant phenotype, whose molecular basis is poorly known. We aim to clarify this issue and to investigate the effects of temozolomide on chemoresistant stem cells. METHODS: A panel of human glioblastoma cultures, grown as stem ce...

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Bibliografiska uppgifter
Huvudupphovsmän: Riganti, Chiara, Salaroglio, Iris Chiara, Caldera, Valentina, Campia, Ivana, Kopecka, Joanna, Mellai, Marta, Annovazzi, Laura, Bosia, Amalia, Ghigo, Dario, Schiffer, Davide
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2013
Ämnen:
Basic and Translational Investigations
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3813413/
https://ncbi.nlm.nih.gov/pubmed/23897632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/not104
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