Temozolomide downregulates P-glycoprotein expression in glioblastoma stem cells by interfering with the Wnt3a/glycogen synthase-3 kinase/β-catenin pathway

BACKGROUND: Glioblastoma multiforme stem cells display a highly chemoresistant phenotype, whose molecular basis is poorly known. We aim to clarify this issue and to investigate the effects of temozolomide on chemoresistant stem cells. METHODS: A panel of human glioblastoma cultures, grown as stem ce...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Riganti, Chiara, Salaroglio, Iris Chiara, Caldera, Valentina, Campia, Ivana, Kopecka, Joanna, Mellai, Marta, Annovazzi, Laura, Bosia, Amalia, Ghigo, Dario, Schiffer, Davide
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
Teme:
Basic and Translational Investigations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3813413/
https://ncbi.nlm.nih.gov/pubmed/23897632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/not104
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki