Antileishmanial Activity, Uptake, and Biodistribution of an Amphotericin B and Poly(α-Glutamic Acid) Complex

A noncovalent, water-soluble complex of amphotericin B (AMB) and poly(α-glutamic acid) (PGA), with AMB loadings ranging from 25 to 55% (wt/wt) using PGA with a molecular weight range of 50,000 to 70,000, was prepared as a potential new treatment for visceral leishmaniasis (VL). The AMB-PGA complex w...

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Main Authors: Mohamed-Ahmed, Abeer H. A., Seifert, Karin, Yardley, Vanessa, Burrell-Saward, Hollie, Brocchini, Stephen, Croft, Simon L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2013
Assuntos:
Susceptibility
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811429/
https://ncbi.nlm.nih.gov/pubmed/23796924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02343-12
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