Telomeric allelic imbalance indicates defective DNA repair and sensitivity to DNA damaging agents

DNA repair competency is one determinant of sensitivity to certain chemotherapy drugs, such as cisplatin. Cancer cells with intact DNA repair can avoid the accumulation of genome damage during growth and also can repair platinum-induced DNA damage. We sought genomic signatures indicative of defectiv...

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Detalhes bibliográficos
Main Authors: Birkbak, Nicolai J., Wang, Zhigang C., Kim, Ji-Young, Eklund, Aron C., Li, Qiyuan, Tian, Ruiyang, Bowman-Colin, Christian, Li, Yang, Greene-Colozzi, April, Iglehart, J. Dirk, Tung, Nadine, Ryan, Paula D., Garber, Judy E., Silver, Daniel P., Szallasi, Zoltan, Richardson, Andrea L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806629/
https://ncbi.nlm.nih.gov/pubmed/22576213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0206
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