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Novel therapeutic approach for hemophilia using gene delivery of an engineered secreted activated Factor VII
Hemophilia is a bleeding disorder caused by mutations in the genes encoding coagulation Factor VIII (FVIII) or FIX. Current treatment is through intravenous infusion of the missing protein. The major complication of treatment is the development of neutralizing Ab’s to the clotting factor. Infusion o...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC379321/ https://ncbi.nlm.nih.gov/pubmed/15057309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420106 |
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