Regulation of human hematopoietic stem cell self-renewal by the microenvironment’s control of retinoic acid signaling

The high expression of aldehyde dehydrogenase 1, also known as retinaldehyde dehydrogenase, by hematopoietic stem cells (HSCs) suggests an important role for retinoic acid (RA) signaling in determining the fate of these cells. We found that primitive human bone marrow-derived CD34(+)CD38(−) cells no...

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Bibliographic Details
Main Authors: Ghiaur, Gabriel, Yegnasubramanian, Srinivasan, Perkins, Brandy, Gucwa, Jessica L., Gerber, Jonathan M., Jones, Richard J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791732/
https://ncbi.nlm.nih.gov/pubmed/24043786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305937110
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