High density of tryptase-positive mast cells in human colorectal cancer: a poor prognostic factor related to protease-activated receptor 2 expression

Tryptase(+) mast cells (MCs), abundant in the invasive front of tumours, contribute to tissue remodelling. Indeed, protease-activated receptor-2 (PAR-2) activation by MC-tryptase is considered an oncogenic event in colorectal cancer (CRC). Recently, we have suggested NHERF1 as a potential new marker...

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Autors principals: Malfettone, Andrea, Silvestris, Nicola, Saponaro, Concetta, Ranieri, Girolamo, Russo, Antonio, Caruso, Stefano, Popescu, Ondina, Simone, Giovanni, Paradiso, Angelo, Mangia, Anita
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2013
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3780541/
https://ncbi.nlm.nih.gov/pubmed/23991686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12073
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