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Forebrain-specific deletion of Cdk5 in pyramidal neurons results in mania-like behavior and cognitive impairment

Cyclin-dependent kinase 5 (Cdk5) is associated with synaptic plasticity and cognitive function. Previous reports have demonstrated that Cdk5 is necessary for memory formation, although others have reported Cdk5 conditional knockout mouse models exhibiting enhanced learning and memory. Furthermore, h...

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Main Authors: Su, Susan C., Rudenko, Andrii, Cho, Sukhee, Tsai, Li-Huei
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775577/
https://ncbi.nlm.nih.gov/pubmed/23850563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nlm.2013.06.016
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