Effects of ezetimibe added to statin therapy on markers of cholesterol absorption and synthesis and LDL-C lowering in hyperlipidemic patients

OBJECTIVE: Statins inhibit cholesterol synthesis but can upregulate cholesterol absorption, with higher doses producing larger effects. Ezetimibe inhibits cholesterol absorption but also upregulates synthesis. We tested whether ezetimibe added to ongoing statin therapy would be most effective in low...

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Main Authors: Thongtang, Nuntakorn, Lin, Jianxin, Schaefer, Ernst J., Lowe, Robert S., Tomassini, Joanne E., Shah, Arvind K., Tershakovec, Andrew M.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749834/
https://ncbi.nlm.nih.gov/pubmed/23040830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2012.09.001
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