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Tumor suppressor gene Rb is required for self-renewal of spermatogonial stem cells in mice
The retinoblastoma tumor suppressor gene Rb is essential for maintaining the quiescence and for regulating the differentiation of somatic stem cells. Inactivation of Rb in somatic stem cells typically leads to their overexpansion, often followed by increased apoptosis, defective terminal differentia...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3732951/ https://ncbi.nlm.nih.gov/pubmed/23858447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311548110 |
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