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Tumor suppressor gene Rb is required for self-renewal of spermatogonial stem cells in mice

The retinoblastoma tumor suppressor gene Rb is essential for maintaining the quiescence and for regulating the differentiation of somatic stem cells. Inactivation of Rb in somatic stem cells typically leads to their overexpansion, often followed by increased apoptosis, defective terminal differentia...

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Bibliografske podrobnosti
Main Authors: Hu, Yueh-Chiang, de Rooij, Dirk G., Page, David C.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732951/
https://ncbi.nlm.nih.gov/pubmed/23858447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311548110
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